Principal Investigator:
Prof. Lorenzo Lo Muzio
Funder: Project funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for tender No. 341 of 15/03/2022 of Italian Ministry of University and Research funded by the European Union – NextGenerationEU
Award Number: Project code PE_00000019, Concession Decree No. 1559 of 11/10/2022 adopted by the Italian Ministry of University and Research, CUP D73C22001230006, “Health Extended ALliance for Innovative Therapies, Advanced Lab-research, and Integrated Approaches of Precision Medicine” (HEAL ITALIA)
Start date: 01/12/2022
End date: 30/11/2025
Total NRRP funding for the whole project: € 114.700.000,00
Total NRRP funding for Unifg: € 6.250.000,00
HEAL Italia represents the first Italian Foundation that coordinates a qualified multidisciplinary network of Universities, IRCCS and Companies, scientists, technologists and young researchers who share knowledge, research and innovative technologies in order to bring our National Health System into the contemporary era of Medicine of Precision through new methods, new services and above all an important network of clinical data to support translational research for advanced diagnoses and therapies in the fight against cancer and cardiovascular, metabolic and rare diseases. The overall cost amounts to €118,765,450.00 and the MUR subsidy amounts to €114,700,000.00. The cascading tenders provide for 10% of the project costs.
The HEAL ITALIA Project aims to strengthen the research and innovation chain in the field of Precision Medicine, also through active participation in the development of value chains considered strategic for the country.
In this context, the HEAL ITALIA Project is conceived with a holistic interdisciplinary vision, capable of combining fundamental and translational research with technology transfer, exploiting the capabilities of the main players in the academic, clinical and private sectors. The Project envisages that the research & development activities will be carried out at eight Spokes, coordinated by the HUB, which acts as the implementing body.
Objectives
The objective of the HEAL ITALIA research project is the creation of research chains, in which public and private sectors operate synergistically in order to support the implementation of processes and the creation of preparatory products for Precision Medicine.
The overall objective of the project is therefore to provide new, cost-effective and evidence-based predictive and non-invasive diagnostic pathways for faster, earlier, more precise, accessible and economical prediction, detection and monitoring of monogenic (rare) diseases. ), polygenic (cardiovascular and metabolic) and cancer, as well as to identify innovative and effective therapeutic approaches. The HEAL ITALIA project also aims to identify and reduce inequalities (extremely large between Northern and Southern Italy) by developing an interregional collaboration roadmap to define evidence-based pathways that can be easily used in clinical practice. The Mission of the HEAL ITALIA Research Program is therefore to facilitate the transition towards efficient methods and tools in terms of costs and time, which allow early diagnosis and frequent screening of patients, two of the cornerstones of approaches to precision medicine.
UNIFG is involved in the following Spokes as executor entity:
- Spoke 1
Holistic Nosology From patients to molecules and back: mapping the omic landscape of clinical to molecular environment, to identify, classify, and refine the phenotypes of multifactorial diseases; - Spoke 3
Prediction models: Advanced prediction models for prognosis and therapeutic response based on comprehensive data treatment; - Spoke 4
4D Precision Diagnostics. Precision medicine integrating clinical and imaging biomarkers for a “precise in space and time” diagnosis; - Spoke 6
Healthy Toolbox: Development of innovative devices for precision diagnosis and personalized therapy; - Spoke 7
Prevention Strategies: Integrated and gender medicine approaches for prevention strategies based on environmental, lifestyle and clinical biometric data;
- Department of Clinical and Experimental Medicine
- Department of Medical and Surgical Sciences
Principal Investigator
Prof. Lorenzo Lo Muzio
SSD: MED/28 - Oral diseases and dentistry
Afferenza: Department of Clinical and Experimental Medicine
Scientific Coordinator for Spoke 1-
Prof. Gaetano Serviddio
SSD: MED/09 - Internal medicine
Afferenza: Department of Medical and Surgical Sciences
Email: [email protected]
Telefono: +39 0881 741587
Scientific Coordinator for Spoke 3-
Prof. Tommaso Cassano
SSD: BIO/14 - Pharmacology
Afferenza: Department of Medical and Surgical Sciences
Email: [email protected]
Scientific Coordinator for Spoke 4-
Prof. Giorgio Mori
SSD: BIO/17 - Histology
Afferenza: Department of Clinical and Experimental Medicine
Email: [email protected]
Scientific Coordinator for Spoke 6-
Prof. Massimo Conese
SSD: MED/04 - Experimental Medicine and Pathophysiology
Afferenza: Department of Clinical and Experimental Medicine
Email: [email protected]
Telefono: +39 0881 558019
Scientific Coordinator for Spoke 7-
Prof. Lucio Lo Russo
SSD: MED/28 - Oral diseases and dentistry
Afferenza: Department of Clinical and Experimental Medicine
Email: [email protected]
Telefono: +39 0881 588085